Description
Thymalin at a glance
Thymalin is described in the published literature as a thymic polypeptide preparation, a mixture rather than one defined peptide, studied mainly for immune-cell markers and in older Russian clinical reports. Nearly all of that research comes from one network of investigators, and modern controlled trials are scarce. Ellepeptides supplies Thymalin as freeze-dried research material in a 10 mg vial, listed in our energy and metabolic research collection.
- Material type: thymic polypeptide preparation, not a single sequence
- Vial size: 10 mg (nominal total)
- Listed price: $56.99 USD
- Form: freeze-dried (lyophilized) powder
- Ships within the US; free shipping when the merchandise subtotal is over $200
- For laboratory research only
Thymalin vial sizes and price per mg
| Vial size | Listed price (USD) | Price per mg |
|---|---|---|
| 10 mg | $56.99 | $5.70 |
Prices are listed in USD at the time of writing; the size selector above shows the current price. Bulk or combination savings through the cart or coupons are not promised.
Thymalin compound profile
| Research name | Thymalin |
|---|---|
| Literature description | Thymic polypeptide complex |
| Nominal amount per vial | 10 mg (total material) |
| Sequence, CAS number, formula, molar mass | None assigned: a multi-component preparation has no single value without composition data |
| Intended scope | Laboratory research |
Unlike a defined peptide, Thymalin has no single reference structure to list. The table therefore describes how the literature classifies the material, not the component profile or analytical make-up of any lot; that needs documentation for the material supplied.
How Thymalin works in research
The thymus is where T cells mature, and Thymalin research starts from the idea that thymus-derived peptides can influence how immune cells develop and mature. A 2020 cell experiment gave that idea its most specific test: cells exposed to a studied Thymalin preparation showed lower CD44 and CD117 expression and higher CD28 expression, marker shifts consistent with cell differentiation. Khavinson et al. (2020)
A 2020 review by investigators from the same tradition summarized their earlier clinical data in acute and chronic diseases, describing normalized cellular and humoral immunity, lower pro-inflammatory cytokines and less intravascular clotting. It proposed, rather than tested, Thymalin with heparin for COVID-19. Kuznik and Khavinson (2020)
Because the material is a mixture, these results do not identify which component, if any single one, is responsible. Marker changes in cultured cells are a hypothesis about mechanism, not a demonstrated pathway in people or animals.
Key Thymalin studies
| Year | Study & model | What was measured | Main finding | Source |
|---|---|---|---|---|
| 2003 | 266 older adults over 6–8 years; Thymalin and/or Epithalamin vs controls | Mortality, respiratory illness, chronic disease | Mortality 2.0–2.1-fold lower with Thymalin; randomization not described | Khavinson and Morozov |
| 2020 | Cultured human cells | CD44, CD117 and CD28 expression | CD44 and CD117 lower, CD28 higher | Khavinson et al. |
| 2020 | Review of the authors’ earlier clinical data | Immunity, clotting, cytokines | Normalization reported; COVID-19 use proposed, not tested | Kuznik and Khavinson |
| 2021 | Randomized study in severe COVID-19, added to then-standard care | Immune markers and clinical course | Differences reported; small, disease-specific | Clinical report |
The long-term cohort. The 2003 follow-up of 266 older adults reported mortality 2.0–2.1-fold lower with Thymalin, 1.6–1.8-fold lower with Epithalamin and 2.5-fold lower with both, compared with controls. The abstract does not describe randomization or how controls were chosen, so the comparison is hard to judge. Khavinson and Morozov (2003)
The COVID-19 study. This randomized report added Thymalin to then-standard care for severe COVID-19 and described immune-marker and clinical differences. It is small and disease-specific and does not show an effect in healthy people. Clinical report
One research tradition. Every source above comes from the same St. Petersburg-centered group and its collaborators; we found no independent replication. Our research page explains how we handle evidence of this kind.
Thymalin research involving women
The 2021 COVID-19 study is the only source here that reports participants by sex: 16 women in the Thymalin group and 21 in the control group. Its results are not broken out for women, and a severe-infection setting says nothing about healthy women. Clinical report
The 2003 cohort abstract does not report a sex breakdown. No source here studies Thymalin in relation to menopause, pregnancy or female hormones, so the women-specific evidence is effectively absent. Our peptides for women hub lists compounds with stronger women-focused notes.
Thymalin vs Epitalon, KPV and Pinealon
| Compound | Type | Main research focus | Sizes on Ellepeptides |
|---|---|---|---|
| Thymalin (this page) | Thymic polypeptide preparation | Immune-cell markers; older clinical reports | 10 mg |
| Epitalon | Synthetic tetrapeptide (AEDG) | Telomerase and aging biomarkers | 10 mg |
| KPV | Synthetic tripeptide (Lys-Pro-Val) | Inflammation research | 10 mg |
| Pinealon | Synthetic tripeptide (EDR) | Oxidative stress in nerve-cell models | 10 mg |
Thymalin is the only mixture in this group; the others are single, defined sequences. Epitalon and Pinealon share Thymalin’s research tradition, while KPV comes from separate inflammation work. None of their results can be borrowed for Thymalin.
Thymalin handling, storage and reconstitution math
Thymalin is supplied as a lyophilized solid. The label is the reference for the stated amount and storage conditions; keep the vial sealed until it is needed and record the lot number alongside your data.
Work in mass concentration: 10 mg in 2 mL gives 5 mg/mL, and 10 mg in 1 mL gives 10 mg/mL. Molar conversions are not meaningful here, because a multi-component preparation has no single molar mass. The peptide calculator handles the mass arithmetic, and bacteriostatic water is often used when one vial is sampled repeatedly. Follow your protocol’s solvent.
Ordering Thymalin in the US
Thymalin orders ship to addresses within the United States. Shipping is free when the merchandise subtotal exceeds $200 after coupon discounts (before taxes and shipping); below that, standard shipping is $15.99 per order. Available payment methods and delivery options are shown at checkout. Current details are in the shipping policy.
Thymalin FAQ
What is Thymalin?
Thymalin is described in the literature as a thymic polypeptide complex: a preparation of several peptides rather than one defined molecule. It is studied for immune-cell markers and in older clinical reports, mostly from one Russian research network. Ellepeptides sells it as freeze-dried research material in a 10 mg vial.
How much does Thymalin cost in the US?
At the time of writing, Ellepeptides lists Thymalin at $56.99 USD for a 10 mg vial, or $5.70 per mg of total material. The product page shows the current price. Shipping is free when the merchandise subtotal is over $200 after coupons; otherwise standard shipping is $15.99.
Where can I buy Thymalin in the US?
Ellepeptides lists Thymalin research vials and ships them to US addresses, with prices in USD. It is sold for laboratory research only. Current rates and the free-shipping threshold are in the shipping policy, and delivery options are shown at checkout.
What has Thymalin research found?
A 2020 cell study reported shifts in CD44, CD117 and CD28 expression, and a 2003 cohort of 266 older adults reported lower mortality with Thymalin than controls, without described randomization. A small 2021 COVID-19 study reported immune differences. All come from one research tradition and lack independent replication.
Thymalin vs thymosin alpha-1: what is the difference?
Thymosin alpha-1 (thymalfasin) is a single, defined 28-amino-acid acetylated peptide, chemically synthesized and identical to the human molecule. Thymalin is described as a multi-peptide thymic preparation without one sequence. Similar thymus-related names do not make them the same material, and Ellepeptides lists only Thymalin.
Thymalin vs Epitalon: how do they differ?
Epitalon is one synthetic tetrapeptide (AEDG); Thymalin is a mixture. In the 2003 older-adult cohort, Thymalin was studied alongside Epithalamin, a pineal extract that is not the same as synthetic Epitalon. Results from that cohort describe neither this vial nor Epitalon.
What side effects of Thymalin have been reported?
The sources on this page do not provide a systematic human safety profile for Thymalin, so no reliable side-effect list can be given. The clinical reports were small or not clearly randomized, and they used specific preparations whose composition cannot be assumed to match a research lot.
Does Thymalin have a single amino-acid sequence?
No. The cited literature treats Thymalin as a peptide complex, so no single sequence, CAS number or molar mass is assigned on this page. The 10 mg figure is the nominal total mass of material, not the amount of any individual component.
Is Thymalin made from calf thymus?
The literature describes Thymalin as a thymic preparation, but a name does not establish the source or manufacturing method of a particular lot. The sources on this page do not verify the origin of this material. For lot-specific questions, email [email protected].
Is Thymalin available as a nasal spray or capsules?
Ellepeptides sells Thymalin only as freeze-dried powder in a sealed vial. The studies summarized here used their own clinical or laboratory preparations, and none of them tested a consumer nasal spray or capsule, so their findings cannot be assumed to describe another form.
Thymalin references
- Khavinson VKh, Morozov VG (2003). Peptides of pineal gland and thymus prolong human life. Neuro Endocrinol Lett 24(3–4):233–240. Journal page.
- Khavinson VKh, et al. (2020). Thymalin and cell-differentiation markers in cultured human cells. PubMed 33237528.
- Kuznik BI, Khavinson VKh (2020). Thymalin, immunity, hemostasis and cytokines (review). Vrach 31(7):18–26. Journal page.
- Thymalin in severe COVID-19: randomized clinical report and participant table (2021). PMC8654498.
- DrugBank. Thymalfasin (thymosin alpha-1), DB04900.
Related research materials: Energy & Metabolic, Anti-Aging & Longevity, Epitalon, KPV, Pinealon and NAD+. For laboratory research only. Not for human or veterinary use.
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